Steve will sacrifice himself for Dustin
In season five trailer, a scared-faced Dustin hugs Steve with tears in his eyes, suggesting one of them may not survive the series.
Dustin and Steve became good friends after the encounter where Dustin sought Steve’s help with a demogorgon, and Steve found himself in a new role as a protector and mentor figure.
Will Steve’s desire to protect Dustin lead him to sacrifice himself because Vecna is coming after them?
This would leave fans shocked and devastated because their friendship has grown so much throughout the show.
Eleven will have to lose her powers to survive
Eleven has multiple powers she uses throughout the show like telekinesis, telepathy, and more. Eleven could possibly lose her powers due to a combination of physical and psychological factors.
Eleven lost her powers in season three due to the battle at the Star Court mall. The injury from the mind flayer attack, combined with the immense stress and trauma she endured, likely damaged her ability to access her powers.
Eleven has had so much happen to her throughout this show, and if she is going to live a normal life with her friends, she will probably have to sacrifice herself or her powers to do it.
Vecna will control Will
Vecna is going to control Will since he has controlled Will in the past, and he has manipulated Will the most out of anyone.
This all started when Will got kidnapped into the Upside Down by Vecna and he ended up getting powers like El. He controlled Will’s speech and body with the mind flayer in season two.
Will and Vecna are both outcasts, which Vecna can use to manipulate Will.
In the season five trailer, Vecna states, “William, you are going to help me.”
While Vecna has been planning to control Will this entire time by having him spy on the friend group through true sight, Will is going to be key to Vecna’s plans.
